Scientific Articles

Day after day, our Customers & Partners are progressing to develop new therapies with Dendrigraft of L-Lysine from proof of concept at lab scale, up to clinical trials


Evaluation of transgene expression characteristics and DNA vaccination against melanoma metastasis of an intravenously injected ternary complex with biodegradable dendrigraft poly-L-lysine in mice

2021 Drug Delivery / Kodama et al. / Keywords: Splenic vector; DNA vaccine; ternary complex; melanoma; gene delivery


2020 Adv. Funct. Mater. / Cai et al. / Keywords: acid-responsive, Alzheimer’s disease, blood–brain barrier transcytosis, neuron targeted

2020 Adv. Healthcare Mater. / Hong et al. / Keywords: low molecular weight heparin, microvascular obstructions, miRNA, myocardial infarctions, nanodelivery

2020 Nanomedicine: Nanotechnology, Biology, and Medicine / Zhao et al. / Keywords: H9N2 avian influenza; Dendrigraft poly-L-lysine; Nanoparticles; Delivery of DNA vaccine; Immune responses


Enhanced lysosome escape mediated by 1,2-dicarboxylic-cyclohexene anhydride-modified poly-L-lysine dendrimer as a gene delivery system

2019 Asian Journal of Pharmaceutical Sciences / Shen et al. / Keywords: Antisense oligodeoxynucleotide (ASODN); Gene delivery; Dendrigraft poly-L-lysines (DGL); Lysosomal escape; Tumor targeting


Delivery of microRNA-1 inhibitor by dendrimer-based nanovector: An early targeting therapy for myocardial infarction in mice

2018 Nanomedicine: Nanotechnology, Biology, and Medicine / Xue et al. / Keywords: Early targeting therapy; Nanovector; Dendrigraft poly-L-lysine; miRNA-1; Myocardial infarction


Application of biodegradable dendrigraft poly-L-lysine to a small interfering RNA delivery system

2016 Journal of Drug Targeting / Sasaki et al. / Keywords: dendrigraft poly-L-lysine; biodegradable; siRNA delivery; γ polyglutamic acid; nanoparticles

Harnessing the PEG-cleavable strategy to balance cytotoxicity, intracellular release and the therapeutic effect of dendrigraft poly-L-lysine for cancer gene therapy

2016 Journal of Chromatography A / Ren et al. / Keywords: gene delivery; cancer therapy; PEG-cleavable strategy


Biodegradable nanoparticles composed of dendrigraft poly-L-lysine for gene delivery

2014 European Journal of Pharmaceutics and Biopharmaceutics / Sasaki et al. / Keywords: Dendrigraft poly-L-lysine, Biodegradable, Gene delivery, c-Polyglutamic acid, Nanoparticle, Ternary complex

A Bacteria Deriving Peptide Modified Dendrigraft Poly‑L‑lysines (DGL) Self-Assembling Nanoplatform for Targeted Gene Delivery

2014 Molecular Pharmaceutics / Jiang et al. / Keywords: brain-targeted, tumor-targeted, gene delivery, laminin receptor, nanoparticles


Acid Active Receptor-Specific Peptide Ligand for In Vivo Tumor-Targeted Delivery

2013 Small / Jiang et al. / Keywords: Targeting therapy of tumors; Drug-delivery systems

Angiopep-Conjugated Nanoparticles for Targeted Long-Term Gene Therapy of Parkinson’s Disease

2013 Pharm. Res. / Jiang et al. / Keywords: angiopep-conjugated nanoparticles, dendrigraft poly-L-lysine, gene therapy, multiple dosing administrations, Parkinson’s disease

Targeting Caspase-3 as Dual Therapeutic Benefits by RNAi Facilitating Brain-Targeted Nanoparticles in a Rat Model of Parkinson’s Disease

2013 PLOS ONE / Jiang et al. / Keywords: Activation of caspase-3; Parkinson’s disease; Brain-targeted gene delivery system; Non-viral gene vector

Brain-targeting delivery for RNAi neuroprotection against cerebral ischemia reperfusion injury

2013 Biomaterials / Jiang et al. / Keywords: Dermorphin, Brain-targeting nanoparticles, RNAi, Ask1, Ischemia/reperfusion injury

Tumor targeting and microenvironment responsive nanoparticles for gene delivery

2013 Biomaterials / Jiang et al. / Keywords: Activatable, Cell-penetrating peptide, Gene delivery, Tumor microenvironment, Tumor targeting nanoparticles


Gene and doxorubicin co-delivery system for targeting therapy of glioma

2012 Biomaterials / Jiang et al. / Keywords: Combination therapy, Doxorubicin, pH-sensitive, Cancer targeting, T7 peptide

In Vitro Transfection Mediated by Dendrigraft Poly(L-lysines): The Effect of Structure and Molecule Size

2012 Macromolecular Bioscience / Cigler et al. / Keywords: dendrigraft poly(L-lysines); dendrimers; drug delivery systems; structure–property relations; transfection


Evaluation and mechanism studies of PEGylated dendrigraft poly-L-lysines as novel gene delivery vectors

2010 Nanotechnology / Huang et al. / Keywords: gene delivery, dendrigraft poly-L-lysines (DGLs), PEGylation, pDNA, DGLs based complexes

A leptin derived 30-amino-acid peptide modified pegylated poly-L-lysine dendrigraft for brain targeted gene delivery

2010 Biomaterials / Liu et al. / Keywords: Brain targeting, Gene delivery, Leptin, Non-viral vector, Dendrigraft poly-L-lysine