Scientific Articles

Day after day, our Customers & Partners are progressing to develop new therapies with Dendrigraft of L-Lysine from proof of concept at lab scale, up to clinical trials


Intranasal Delivery of BACE1 siRNA and Rapamycin by Dual Targets Modified Nanoparticles for Alzheimer’s Disease Therapy

2022 Small / Yang et al. / Keywords: Aleuria Aurantia Lectin, Alzheimer’s disease, Amyloid-β, Autophagy, Intranasal Administration


Delivery of pDNA to the Lung by Lipopolyplexes Using N-Lauroylsarcosine and Effect on the Pulmonary Fibrosis

2021 Pharmaceutics / Kurosaki et al. / Keywords: gene delivery; shRNA; nanoparticles; pulmonary fibrosis; N-lauroylsarcosine

Gene-Activated Matrix with Self-Assembly Anionic Nano-Device Containing Plasmid DNAs for Rat Cranial Bone Augmentation

2021 Materials / Hara et al. / Keywords: bone augmentation; in vivo gene delivery; gene-activated matrix; plasmid vector; self-assembly nano-device

Enhanced endosomal escape of dendrigraft poly-L-lysine polymers for the efficient gene therapy of breast cancer

2021 Nano Research / Ye et al. / Keywords: dendrigraft poly-L-lysine, siRNA delivery, gene therapy, endosomal escape

Evaluation of transgene expression characteristics and DNA vaccination against melanoma metastasis of an intravenously injected ternary complex with biodegradable dendrigraft poly-L-lysine in mice

2021 Drug Delivery / Kodama et al. / Keywords: Splenic vector; DNA vaccine; ternary complex; melanoma; gene delivery


2020 Adv. Funct. Mater. / Cai et al. / Keywords: acid-responsive, Alzheimer’s disease, blood–brain barrier transcytosis, neuron targeted

2020 Adv. Healthcare Mater. / Hong et al. / Keywords: low molecular weight heparin, microvascular obstructions, miRNA, myocardial infarctions, nanodelivery

2020 Nanomedicine: Nanotechnology, Biology, and Medicine / Zhao et al. / Keywords: H9N2 avian influenza; Dendrigraft poly-L-lysine; Nanoparticles; Delivery of DNA vaccine; Immune responses


Enhanced lysosome escape mediated by 1,2-dicarboxylic-cyclohexene anhydride-modified poly-L-lysine dendrimer as a gene delivery system

2019 Asian Journal of Pharmaceutical Sciences / Shen et al. / Keywords: Antisense oligodeoxynucleotide (ASODN); Gene delivery; Dendrigraft poly-L-lysines (DGL); Lysosomal escape; Tumor targeting


Delivery of microRNA-1 inhibitor by dendrimer-based nanovector: An early targeting therapy for myocardial infarction in mice

2018 Nanomedicine: Nanotechnology, Biology, and Medicine / Xue et al. / Keywords: Early targeting therapy; Nanovector; Dendrigraft poly-L-lysine; miRNA-1; Myocardial infarction


Application of biodegradable dendrigraft poly-L-lysine to a small interfering RNA delivery system

2016 Journal of Drug Targeting / Sasaki et al. / Keywords: dendrigraft poly-L-lysine; biodegradable; siRNA delivery; γ polyglutamic acid; nanoparticles

Harnessing the PEG-cleavable strategy to balance cytotoxicity, intracellular release and the therapeutic effect of dendrigraft poly-L-lysine for cancer gene therapy

2016 Journal of Chromatography A / Ren et al. / Keywords: gene delivery; cancer therapy; PEG-cleavable strategy


Biodegradable nanoparticles composed of dendrigraft poly-L-lysine for gene delivery

2014 European Journal of Pharmaceutics and Biopharmaceutics / Sasaki et al. / Keywords: Dendrigraft poly-L-lysine, Biodegradable, Gene delivery, c-Polyglutamic acid, Nanoparticle, Ternary complex

A Bacteria Deriving Peptide Modified Dendrigraft Poly‑L‑lysines (DGL) Self-Assembling Nanoplatform for Targeted Gene Delivery

2014 Molecular Pharmaceutics / Jiang et al. / Keywords: brain-targeted, tumor-targeted, gene delivery, laminin receptor, nanoparticles


Acid Active Receptor-Specific Peptide Ligand for In Vivo Tumor-Targeted Delivery

2013 Small / Jiang et al. / Keywords: Targeting therapy of tumors; Drug-delivery systems

Angiopep-Conjugated Nanoparticles for Targeted Long-Term Gene Therapy of Parkinson’s Disease

2013 Pharm. Res. / Jiang et al. / Keywords: angiopep-conjugated nanoparticles, dendrigraft poly-L-lysine, gene therapy, multiple dosing administrations, Parkinson’s disease

Targeting Caspase-3 as Dual Therapeutic Benefits by RNAi Facilitating Brain-Targeted Nanoparticles in a Rat Model of Parkinson’s Disease

2013 PLOS ONE / Jiang et al. / Keywords: Activation of caspase-3; Parkinson’s disease; Brain-targeted gene delivery system; Non-viral gene vector

Brain-targeting delivery for RNAi neuroprotection against cerebral ischemia reperfusion injury

2013 Biomaterials / Jiang et al. / Keywords: Dermorphin, Brain-targeting nanoparticles, RNAi, Ask1, Ischemia/reperfusion injury

Tumor targeting and microenvironment responsive nanoparticles for gene delivery

2013 Biomaterials / Jiang et al. / Keywords: Activatable, Cell-penetrating peptide, Gene delivery, Tumor microenvironment, Tumor targeting nanoparticles


Gene and doxorubicin co-delivery system for targeting therapy of glioma

2012 Biomaterials / Jiang et al. / Keywords: Combination therapy, Doxorubicin, pH-sensitive, Cancer targeting, T7 peptide

In Vitro Transfection Mediated by Dendrigraft Poly(L-lysines): The Effect of Structure and Molecule Size

2012 Macromolecular Bioscience / Cigler et al. / Keywords: dendrigraft poly(L-lysines); dendrimers; drug delivery systems; structure–property relations; transfection


Evaluation and mechanism studies of PEGylated dendrigraft poly-L-lysines as novel gene delivery vectors

2010 Nanotechnology / Huang et al. / Keywords: gene delivery, dendrigraft poly-L-lysines (DGLs), PEGylation, pDNA, DGLs based complexes

A leptin derived 30-amino-acid peptide modified pegylated poly-L-lysine dendrigraft for brain targeted gene delivery

2010 Biomaterials / Liu et al. / Keywords: Brain targeting, Gene delivery, Leptin, Non-viral vector, Dendrigraft poly-L-lysine