Scientific Articles

Day after day, our Customers & Partners are progressing to develop new therapies with Dendrigraft of L-Lysine from proof of concept at lab scale, up to clinical trials


Effect of Dendrigraft Generation on the Interaction between Anionic Polyelectrolytes and Dendrigraft Poly(L-Lysine)

2018 Polymers / Cottet et al. / Keywords: polyelectrolyte complexes; dendrimers; frontal analysis continuous capillary electrophoresis; counter-ion release; binding constants; ionic strength dependence

Everything You Always Wanted to Know about Poly-L-lysine Dendrigrafts (But Were Afraid to Ask)

2018 Chem. Eur. J. / Vial et al. / Keywords: antibacterial agents · biosensing · dendritic polymers · material and tissue engineering · non-viral vectors · poly-l-lysines


Digitizing Poly‑L‑lysine Dendrigrafts: From Experimental Data to Molecular Dynamics Simulations

2017 J. Chem. Inf. Model. / Vial et al. / Keywords: three-dimensional structures of poly-L-lysine dendrigrafts and the subsequent investigation of their structural features


Frit inlet field-flow fractionation techniques for the characterization of polyion complex self-assemblies

2016 Journal of Chromatography A / Mingotaud et al. / Keywords: Flow field flow fractionation, Frit inlet flow field-flow fractionation, Polyion complex micelles, Polymers, Self-assembly


A KISS (Keep It Simple, Sensor) Array for Glycosaminoglycans

2015 Chemical Communications / Vial et al. / Keywords: dendri-graft poly-L-lysine, complex, heparin, fluorescence titration

Taking Advantage of Electric Field Induced Bacterial Aggregation for the Study of Interactions between Bacteria and Macromolecules by Capillary Electrophoresis

2015 Analytical Chemistry / Cottet et al. / Keywords: dendrigraft poly-L-lysines, bacterial aggregation phenomenon, quantitification

On-line capillary electrophoresis-based enzymatic methodology for the study of polymer-drug conjugates

2015 Journal of Chromatography A / Coussot et al. / Keywords: Capillary electrophoresis, On-line trypsin digestion, Biodegradable polymers, Nano-enzyme reactor


Molar-Mass Analysis of Dendrigraft Poly(L-lysine) (DGL) Polyelectrolytes by SEC-MALLS: The “Cornerstone” Refractive Index Increment

2014 Macromol. Chem. Phys. / Ladavière et al. / Keywords: dendrigrafts, molecular-weight distribution, polyelectrolytes, refractive-index increment, SEC-MALLS

Multi-Technique Characterization of Poly-L-Lysine Dendrigrafts-Cu(II) Complexes for Biocatalysis

2014 Macromolecular Bioscience / Rossi et al. / Keywords: circular dichroism, EPR spectroscopy, poly-L-lysine dendrigrafts, potentiometric titrations, UV-vis spectroscopy

Effect of Dendrimer Generation on the Interactions between Human Serum Albumin and Dendrigraft Polylysines

2014 Langmuir / Cottet et al. / Keywords: DGL, HSA, capillary electrophoresis


Monitoring surface functionalization of dendrigraft poly-l-lysines via click chemistry by capillary electrophoresis and Taylor dispersion analysis

2013 Journal of Chromatography A / Cottet et al. / Keywords: Polymer characterization, Taylor dispersion analysis, Click chemistry, Pressure assisted capillary electrophoresis

Effective Charge Determination of Dendrigraft Poly‑L‑lysine by Capillary Isotachophoresis

2013 Macromolecules / Ibrahim et al. / Keywords: Capillary isotachophoresis; Effective charge determination; Manning theory

The effect of poly-l-lysine structure on the pH response of polygalacturonic acid-based multilayers

2013 Carbohydrate Polymers / Parker et al. / Keywords: Polysaccharide, Polyamino acid, Dendrimer, Disassembly, Dual polarisation interferometer, Multilayer

Study of interactions between oppositely charged dendrigraft poly-l-lysine and human serum albumin by continuous frontal analysis capillary electrophoresis and fluorescence spectroscopy

2013 Journal of Chromatography A / Sisavath et al. / Keywords: Frontal analysis continuous capillary, electrophoresis, Binding constant, Dendrimers, Human serum albumin, Fluorescence spectroscopy


Hydrodynamic Behavior of Dendrigraft Polylysines in Water and Dimethylformamide

2012 Polymers / Yevlampieva et al. / Keywords: dendrimer; dendrigraft polylysine; hydrodynamic properties; hydrodynamic radius; diffusion coefficient

Functionalisation of free amino groups of lysine dendrigraft (DGL) polymers

2012 Tetrahedron Letters / Rossi et al. / Keywords: Lysine dendrigrafts, Chemical grafting, Biopolymers

Electroanalytical Behavior of Poly-L-Lysine Dendrigrafts at the Interface between Two Immiscible Electrolyte Solutions

2012 Analytical Chemistry / Herzog et al. / Keywords: Electrochemical behavior; Immiscible electrolyte solutions; ITIES; Electrochemical response; Proteins structure


Aminated dendritic surfaces characterization: a rapid and versatile colorimetric assay for estimating the amine density and coating stability

2011 Anal. Bioanal. Chem. / Coussot et al. / Keywords: Colorimetric assay, Aminated surfaces, Solid support characterization,  Dendrimers,  Coating stability, ADECA

A rapid and reversible colorimetric assay for the characterization of aminated solid surfaces

2011 Anal. Bioanal. Chem. / Coussot et al. / Keywords: Coomassie blue, Quantification, Amine density, Solid support characterization, ADECA


Neutral Coatings for the Study of Polycation/ Multicharged Anion Interactions by Capillary Electrophoresis: Application to Dendrigraft Poly-L-lysines with Negatively Multicharged Molecules

2010 Analytical Chemistry / Zou et al. / Keywords: Protein-polyelectrolyte; Polylysine; Electrostatics; Electrophoresis

Synthesis and ligation ability of mono aminooxy-functionalized dendrigraft poly-L-lysine (DGL)

2010 Tetrahedron Letters / Bondia et al. / Keywords: Tetraethylene glycol; TEG; Dendrigraft poly-L-lysines; N-carboxyanhydride; Aminooxy group; Ligation; Aldehyde group

An Expeditious Multigram-Scale Synthesis of Lysine Dendrigraft (DGL) Polymers by Aqueous N-Carboxyanhydride Polycondensation

2010 Chem. Eur. J. / Collet et al. / Keywords: Carboxyanhydrides; Dendrimers; Polylysine; Polymerization; Polymers


Colorimetric quantification of amino groups in linear and dendritic structures

2009 Polym. Int. / Coussot et al. / Keywords: Coomassie blue; amino group quantification; poly(amino acid)s; dendrimer; dendrigrafted lysine

Poly(L-proline) II Helix Propensities in Poly(L-lysine) Dendrigraft Generations from Vibrational Raman Optical Activity

2009 Biomacromolecules / Johannessen et al. / Keywords: Vibrational Raman optical activity (ROA), poly(L-lysine) dendrigrafts (DGLs), linear poly(L-lysine)s, DGLs nonimmunogenic properties


Determination of Dendrigraft Poly-L-Lysine Diffusion Coefficients by Taylor Dispersion Analysis

2007 Biomacromolecules / Cottet et al. / Keywords: poly(L-lysine) dendrigrafts (DGLs), Diffusion coefficients, hydrodynamic radius, Taylor dispersion analysis (TDA), dynamic light scattering, size exclusion chromatography